Novel APC-like properties of human NK cells directly regulate T cell activation
نویسندگان
چکیده
1The Lautenberg Center for General and Tumor Immunology, Hebrew University–Hadassah Medical School, Jerusalem, Israel. 2Biogen Idec Inc., San Diego, California, USA. 3Institute of Immunology, University of Oslo, Oslo, Norway. 4Interfakultares Institut für Zellbiologie, Abteilung Immunologie, Tubingen, Germany. 5Department of Microbiology and Immunology, Ben-Gurion University, Beer Sheva, Israel. 6The Laboratory for Cellular and Molecular Immunology, Department of Medicine, and 7Department of Obstetrics and Gynecology, Hadassah Hospital, Jerusalem, Israel. 8Benaroya Research Institute, Seattle, Washington, USA.
منابع مشابه
Retraction. Novel APC-like properties of human NK cells directly regulate T cell activation.
Initiation of the adaptive immune response is dependent on the priming of naive T cells by APCs. Proteomic analysis of unactivated and activated human NK cell membrane-enriched fractions demonstrated that activated NK cells can efficiently stimulate T cells, since they upregulate MHC class II molecules and multiple ligands for TCR costimulatory molecules. Furthermore, by manipulating antigen ad...
متن کاملEffect of Soluble HLA Class I Molecule on NK/LAK Cells Activation Induced by Poly I:C
Background: Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules. These receptors could induce signals that determine NK cells ability to mediate cytotoxicity. Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective: To evaluate the influence of sHLA and two monoclonal an...
متن کاملThe Influence of Perforin Expression on the Sensitivity of LAK/NK Killing Against Various Tumor Target Cells
Background: Perforin is known to be important in cytolytic activity mediated by natural killer (NK) cells. Objective: To study the relationship between the efficiency of NK and lymphokine-activated killer (LAK) cells activity, and the expression of perforin and HLA class I molecules. Methods: LAK cells were generated by in vitro culturing of human peripheral blood lymphocytes (PBLs) in the ...
متن کاملAPC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA.
Toll-like receptors (TLRs) play a fundamental role in the recognition of bacteria and viruses. TLR3 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic mimetic of viral RNA. We show that NK cells, known for their capacity to eliminate virally infected cells, express TLR3 and up-regulate TLR3 mRNA upon poly(I:C) stimulation. Treatment of highly purified NK ce...
متن کاملجدا سازی و تخلیص زیر مجموعه های سلول های کشنده طبیعی با استفاده از مایع رویی کشت سلول های تک هسته ای به کمک PHA و ارزیابی قدرت کشندگی آنها
Natural Killer (NK) cells are the main lymphocyte population expressing P75 B chain of the IL-2 receptor (IL-2R). Consequently, incubation of peripheral blood lymphocytes with IL-2 induce selective activation of NK cells and results in NK activity and generation of Lymphokine activated killer (LAK) cells activity and proliferation. One of the early events during IL-2 activation of peripheral bl...
متن کامل